The talk show Titan Oprah will me calling the quits after 25 years on the air. The Oprah Show was and still is the longest running daytime talk show that has ever aired. She will announce the news officially on her show, Friday November 20th. Discovery Communications CEO David Zaslav today said his company, which is partnering with Ms. Winfrey to launch the Oprah Winfrey Network on cable next year, expects her to terminate “The Oprah Winfrey Show” in 2011, when her contract expires, to focus on OWN.

We are thrilled that ‘The Oprah Winfrey Show’ will continue production through the 2010–2011 season, its 25th year on the air,” CBS Television Distribution said in a statement. “We are grateful to Ms. Winfrey, her producers and all of our affiliates who remain committed to bringing viewers this exceptional series. We would certainly welcome and hope that ‘The Oprah Winfrey Show’ would continue in syndication beyond that, but that is a decision only Ms. Winfrey will be making.”